We aimed to understand how gelatin-coated zinc and sulfur nanoparticles could potentially treat rheumatoid arthritis, a common autoimmune disorder. Our research involved testing these smart nanoparticles on normal and arthritis-affected rats.
The results were promising; the nanoparticles reduced inflammation and joint swelling significantly. We observed that they lowered harmful cytokines while boosting beneficial antioxidant enzymes. However, we must note that the effectiveness varied based on dosage, and no definitive conclusions were reached regarding their overall impact on rheumatoid arthritis in humans.
Read More
8
Gelatin effective for arthritis therapy
Injectable bioadhesive hydrogel as a local nanomedicine depot for targeted regulation of inflammation and ferroptosis in rheumatoid arthritis.
We explored a novel treatment approach using a gelatin-based hydrogel to enhance the delivery of anti-inflammatory nanoparticles in rheumatoid arthritis (RA). This hydrogel acts as a local depot for the nanoparticles, improving their ability to reach and impact macrophages directly.
Through laboratory tests, we noticed significant suppression of inflammation and protection of joint cartilage. The hydrogel helps the nanoparticles stick to joint tissues, leading to sustained therapy and better functional recovery of the joints. Overall, this study suggests that gelatin-based treatments could offer a promising way to manage RA symptoms effectively.
Read More
8
Gelatin hydrogel aids kidney regeneration
Improvement of IgA Nephropathy and Kidney Regeneration by Functionalized Hyaluronic Acid and Gelatin Hydrogel.
We explored how a special bioactive hydrogel made from hyaluronic acid and gelatin can help treat IgA nephropathy, a kidney disease. The hydrogel was tested on mice using human kidney cells to see if it would improve kidney function and regeneration.
Our findings showed that this hydrogel not only supported cell growth but also significantly reduced harmful substances in the blood and improved the structure of kidney tissue. However, while the hydrogel showed promise in enhancing kidney regeneration, it’s essential to continue exploring its effectiveness in larger studies.
Read More
Most Useful Reviews
9
Weather-related relief
2 people found this helpful
For my grandmother, her knees reacted strongly to weather changes, which made walking difficult on snowy or rainy days. After learning about how gelatin can reduce these issues, I bought a jar for her. I regularly order it now as it has been effective for joint problems. I highly recommend it for anyone facing similar issues.
Read More
10
Amazing results
1 people found this helpful
The effect is amazing! I switched to gelatin capsules after using regular gelatin. With existing joint issues, I started taking it and have had no side effects. I've ordered three more jars due to the positive results. My knees have stopped hurting and crunching, and I highly recommend it for quality and ease of use.
Read More
9
Effective supplement
1 people found this helpful
Excellent gelatin! I've used two jars, taking three capsules daily alongside collagen, omega, and biotin. The effects are evident! My skin is smooth and silky, my hair grows much faster, and my injured knee has only bothered me once during an extended period of use, even in damp "arthritic" weather. I will order this gelatin again.
We aimed to investigate how gelatin nanoparticles containing aescin (Ze@Aes-GNPs) influence rheumatoid arthritis, a painful autoimmune disorder.
Through a careful design involving nanoparticles created via nanotechnology, we tested their effectiveness in reducing joint inflammation in rats.
Both aescin alone and the nanoparticles showed a decrease in swelling and inflammation markers. However, we found that the gelatin nanoparticles were superior at alleviating symptoms and reducing oxidative stress compared to aescin alone.
Overall, the findings suggest that Ze@Aes-GNPs may be a more effective treatment option for arthritis inflammation.
Read More
9
Rutin nanoparticles show promise
Rutin-loaded chitosan nanoparticles alleviated Freund's adjuvant induced rheumatoid arthritis via modulating oxidative stress and inflammatory parameters in Wistar rats.
We investigated the potential benefits of rutin nanoparticles in treating rheumatoid arthritis in a rat model. Sixty male rats were divided into groups and received different treatments, including rutin formulations and a positive control drug.
Our results showed that treatment with rutin nanoparticles improved behavior and reduced signs of inflammation in the rats. Notably, they decreased harmful substances while boosting beneficial ones, enhancing overall health indicators.
While these findings are promising, it’s important to note that further studies are needed to fully understand the efficacy in humans.
Read More
9
Gelatin-based nanoparticles show promise
Dose-Dependent Efficacy of Umbelliferone and Gelatin-Coated ZnO/ZnS Core-Shell Nanoparticles: A Novel Arthritis Agent for Severe Knee Arthritis.
We aimed to understand how gelatin-coated zinc and sulfur nanoparticles could potentially treat rheumatoid arthritis, a common autoimmune disorder. Our research involved testing these smart nanoparticles on normal and arthritis-affected rats.
The results were promising; the nanoparticles reduced inflammation and joint swelling significantly. We observed that they lowered harmful cytokines while boosting beneficial antioxidant enzymes. However, we must note that the effectiveness varied based on dosage, and no definitive conclusions were reached regarding their overall impact on rheumatoid arthritis in humans.
Read More
8
Gelatin effective for arthritis therapy
Injectable bioadhesive hydrogel as a local nanomedicine depot for targeted regulation of inflammation and ferroptosis in rheumatoid arthritis.
We explored a novel treatment approach using a gelatin-based hydrogel to enhance the delivery of anti-inflammatory nanoparticles in rheumatoid arthritis (RA). This hydrogel acts as a local depot for the nanoparticles, improving their ability to reach and impact macrophages directly.
Through laboratory tests, we noticed significant suppression of inflammation and protection of joint cartilage. The hydrogel helps the nanoparticles stick to joint tissues, leading to sustained therapy and better functional recovery of the joints. Overall, this study suggests that gelatin-based treatments could offer a promising way to manage RA symptoms effectively.
Read More
8
Gelatin hydrogel aids kidney regeneration
Improvement of IgA Nephropathy and Kidney Regeneration by Functionalized Hyaluronic Acid and Gelatin Hydrogel.
We explored how a special bioactive hydrogel made from hyaluronic acid and gelatin can help treat IgA nephropathy, a kidney disease. The hydrogel was tested on mice using human kidney cells to see if it would improve kidney function and regeneration.
Our findings showed that this hydrogel not only supported cell growth but also significantly reduced harmful substances in the blood and improved the structure of kidney tissue. However, while the hydrogel showed promise in enhancing kidney regeneration, it’s essential to continue exploring its effectiveness in larger studies.
For my grandmother, her knees reacted strongly to weather changes, which made walking difficult on snowy or rainy days. After learning about how gelatin can reduce these issues, I bought a jar for her. I regularly order it now as it has been effective for joint problems. I highly recommend it for anyone facing similar issues.
Read More
10
Amazing results
1 people found this helpful
The effect is amazing! I switched to gelatin capsules after using regular gelatin. With existing joint issues, I started taking it and have had no side effects. I've ordered three more jars due to the positive results. My knees have stopped hurting and crunching, and I highly recommend it for quality and ease of use.
Read More
9
Effective supplement
1 people found this helpful
Excellent gelatin! I've used two jars, taking three capsules daily alongside collagen, omega, and biotin. The effects are evident! My skin is smooth and silky, my hair grows much faster, and my injured knee has only bothered me once during an extended period of use, even in damp "arthritic" weather. I will order this gelatin again.
Read More
9
Satisfied customer
1 people found this helpful
I'm extremely happy with this order! The product is as described and fairly priced, with swift shipping to Canada. It’s challenging to find in Canada, so I’m thrilled to have discovered it. This is the one product that helps my nails grow strong!
Read More
9
Reduced knee pain
I first ordered it for a friend suffering from knee pain. After she finished a jar, I noticed a positive effect, as the pain ceased. I also found benefits in my skin, becoming more nourished as a result of this product.
An autoimmune disorder occurs when the body's immune system mistakenly attacks its own healthy cells and tissues, believing them to be foreign invaders, such as bacteria or viruses. This reaction can lead to inflammation, tissue damage, and impaired function of the affected organs. There are over 80 known autoimmune diseases, including rheumatoid arthritis, lupus, multiple sclerosis, and type 1 diabetes, each with its own specific symptoms and treatment options. The exact cause of these disorders is still unclear, but a combination of genetic, environmental, and hormonal factors is believed to play a role in their development.
Diagnosis of autoimmune disorders often involves a combination of physical examinations, assessment of symptoms, blood tests, and imaging studies to evaluate organ involvement. Treatment typically focuses on managing symptoms and controlling the immune response using medications such as corticosteroids, immunosuppressants, and biologics. In addition to medication, lifestyle modifications, such as stress management and a balanced diet, can be beneficial in managing symptoms. If you suspect you have an autoimmune condition, it's important to consult a healthcare professional for proper evaluation and tailored treatment options.
Gelatin is a colorless, flavorless food ingredient derived from collagen, which is a protein obtained from the skins, bones, and connective tissues of animals, most commonly pigs and cows. It is widely used in the culinary world to thicken, stabilize, or add body to a variety of foods such as Jell-O, gummy candies, marshmallows, and certain dairy products. Additionally, gelatin serves as a gelling agent in desserts, sauces, and even some beverages, thanks to its unique ability to form a gel-like consistency when dissolved in hot liquid and then cooled.
In the realm of health and nutrition, gelatin is praised for its potential benefits, including supporting joint health, improving skin elasticity, and aiding digestion. While it's primarily found in food products, gelatin is also used in pharmaceuticals, cosmetics, and even photography. For those following vegetarian or vegan diets, there are plant-based alternatives available, such as agar-agar and pectin, which can provide similar gelling properties without using animal-derived ingredients. Overall, gelatin is a versatile ingredient, valued in both the kitchen and wellness circles for its functional properties.
Based on user reviews, the time it takes to see results from the gelatin supplement can vary significantly among individuals. Many users report noticing improvements within just a few days. For instance, one user mentioned feeling relief from joint clicking by the second or third day of taking the product Read Review, while others have observed benefits after a month or longer. Some users noticed positive effects on their hair and nails after a month of continuous use Read Review.
However, for a more sustained and noticeable impact, especially regarding joint health or skin improvements, many recommend a longer timeframe of at least three months Read Review. Results appear to be cumulative, meaning users often see more significant benefits the longer they take the supplement, making continued use essential to evaluate the full effects Read Review.
Research on various supplements and treatments for autoimmune disorders, particularly rheumatoid arthritis, indicates some promising developments. For instance, studies involving gelatin-based hydrogels and nanoparticles have shown effectiveness in reducing inflammation and improving joint function in animal models. One study highlighted the use of gelatin-based hydrogel as a delivery system for anti-inflammatory nanoparticles, leading to significant suppression of inflammation and protection of joint cartilage, suggesting a novel approach for managing rheumatoid arthritis symptoms [1]. Another investigation focused on gelatin nanoparticles containing aescin, which demonstrated superior inflammation reduction compared to aescin alone, presenting a potential new treatment method for arthritis [2].
While the research suggests that these treatments could be beneficial, it's important to note that most studies have been conducted in animal models, indicating the need for further clinical trials in humans to establish effectiveness and safety in treating autoimmune disorders. Treatments using other nanoparticle formulations, like rutin and zinc/sulfur, also showed positive outcomes in reducing inflammation within arthritis-affected rats, although definitive conclusions regarding their applicability to human conditions remain unconfirmed [3][5]. Overall, while these findings are encouraging, ongoing research is vital before any specific supplement can be definitively recommended for autoimmune disorders.
Based on user reviews, many individuals have reported notable improvements in various symptoms after taking the gelatin supplement. A common theme is the alleviation of joint pain, particularly in the knees, with several users indicating complete relief from discomfort and crunching noises after consistent use Read Review. Some users, like those taking it for arthritic symptoms, have observed better mobility and significantly reduced joint pain during activity, often crediting the supplement for their enhanced comfort Read Review.
Additionally, reports of improved skin, hair, and nail health are prevalent among users. For example, one user noted smoother skin and accelerated hair growth after a month of use, while others highlighted strengthened nails and reduced skin dryness Read Review. However, it’s important to recognize that results can vary, with some users experiencing minimal effects on skin and nails, emphasizing the need for consistent usage to fully assess potential benefits Read Review.
According to user reviews, several individuals with autoimmune disorders have found notable benefits when combining the gelatin supplement with other products such as collagen, omega-3, and biotin. One user specifically mentioned taking gelatin alongside these supplements and observed significant improvements in skin texture, hair growth, and joint discomfort, particularly in challenging weather conditions Read Review. Additionally, another user reported enhanced results for hair and skin elasticity when introducing ascorbic acid and omega-3 to their gelatin intake, highlighting a potential synergistic effect between these supplements Read Review.
Users emphasized that individual results can vary, but many noted cumulative benefits when they consistently combined gelatin with other supplements tailored for joint and skin health. Regular use appears to provide compounded effects over time, particularly in alleviating symptoms related to autoimmune disorders, such as joint pain and skin issues Read Review. As many users advocate for the pairing of gelatin with biotin and collagen, it may be worth considering for anyone managing similar health challenges Read Review.
Based on user reviews, it seems that the optimal dosage for gelatin varies, but many users report positive results with a range of one to three capsules taken daily. For example, one user noted significant improvements in knee discomfort when adhering to a recommended dosage of two capsules daily, leading to a reduction in crunching sounds and discomfort in the joints Read Review. Another user reported taking three capsules per day along with other supplements, leading to evident effects on skin and joint issues Read Review.
Additionally, there are users who found success with varied dosing practices; one mentioned taking one to two capsules daily and felt that the dosage felt individual, implying that personalization may play a role Read Review. It's clear that while users generally found relief from joint pain and improvements in skin and hair health, the right dose could depend on personal health needs and responses. Users consistently highlight the importance of maintaining regular intake for cumulative benefits.
9
No joint clicking
3 people found this helpful
I felt relief from joint clicking by the second or third day of taking gelatin. It seems to have been effective for me. Though it didn’t strengthen my nails, I was very satisfied with the product overall. Next time, I may take biotin for my nails.
7.5
Positive results
3 people found this helpful
I ordered this as gifts for my colleagues, and everyone noted a positive effect after a month. Their nails no longer peeled, and one colleague mentioned hair growth for the first time. I believe this is a terrific product for those struggling with autoimmune disorders affecting their hair and nails.
7.5
Joint relief
I have been taking this for three months, as recommended by my osteopath. I constantly order it; while I didn't notice significant effects on my hair, nails, or skin, my joint symptoms have lessened, which is a positive outcome.
7.5
Cumulative effects
7 people found this helpful
I order this gelatin regularly for both myself and my relatives. The effects are cumulative; I've noticed significant improvement on my skin, as peeling has stopped and it's more elastic. While the effect on my nails is less pronounced, my hair is growing faster and becoming less brittle. Small capsules ensure no issues with consumption!
10
Amazing results
1 people found this helpful
The effect is amazing! I switched to gelatin capsules after using regular gelatin. With existing joint issues, I started taking it and have had no side effects. I've ordered three more jars due to the positive results. My knees have stopped hurting and crunching, and I highly recommend it for quality and ease of use.
9
Knee discomfort gone
1 people found this helpful
I ordered this for a friend experiencing discomfort in the knees during sports, which led to a crunching sound. After using it, the crunch has disappeared, and the discomfort is gone during exercise, allowing for increased activity. I plan to order for myself as well. Highly recommend!
9
Effective supplement
1 people found this helpful
Excellent gelatin! I've used two jars, taking three capsules daily alongside collagen, omega, and biotin. The effects are evident! My skin is smooth and silky, my hair grows much faster, and my injured knee has only bothered me once during an extended period of use, even in damp "arthritic" weather. I will order this gelatin again.
7.5
Skin and joint improvement
4 people found this helpful
Initially, I ordered this gelatin for my joints and tendons. However, I soon realised it also benefits hair and skin. I began taking three capsules of gelatin, plus Omega-3 and ascorbic acid. Surprisingly, I noticed my hair growing rapidly, and my skin improved, becoming more elastic with fewer visible wrinkles. The capsules are small, easy to swallow, and have no aftertaste.
9
Highly recommended!
7 people found this helpful
I recommend this product! This is my second order. I’ve noticed that when I follow the dosage, my knees stop crunching and the discomfort goes away. I wholeheartedly endorse it! 👍
7.5
New hair growth
1 people found this helpful
This is my second order, and I have observed significant new hair growth as well as a considerable strengthening of my nails! I initially took two pills a day and sometimes one or two; it feels individual, but I highly recommend it.
8
Gelatin effective for arthritis therapy
Injectable bioadhesive hydrogel as a local nanomedicine depot for targeted regulation of inflammation and ferroptosis in rheumatoid arthritis.
We explored a novel treatment approach using a gelatin-based hydrogel to enhance the delivery of anti-inflammatory nanoparticles in rheumatoid arthritis (RA). This hydrogel acts as a local depot for the nanoparticles, improving their ability to reach and impact macrophages directly.
Through laboratory tests, we noticed significant suppression of inflammation and protection of joint cartilage. The hydrogel helps the nanoparticles stick to joint tissues, leading to sustained therapy and better functional recovery of the joints. Overall, this study suggests that gelatin-based treatments could offer a promising way to manage RA symptoms effectively.
We aimed to investigate how gelatin nanoparticles containing aescin (Ze@Aes-GNPs) influence rheumatoid arthritis, a painful autoimmune disorder.
Through a careful design involving nanoparticles created via nanotechnology, we tested their effectiveness in reducing joint inflammation in rats.
Both aescin alone and the nanoparticles showed a decrease in swelling and inflammation markers. However, we found that the gelatin nanoparticles were superior at alleviating symptoms and reducing oxidative stress compared to aescin alone.
Overall, the findings suggest that Ze@Aes-GNPs may be a more effective treatment option for arthritis inflammation.
9
Rutin nanoparticles show promise
Rutin-loaded chitosan nanoparticles alleviated Freund's adjuvant induced rheumatoid arthritis via modulating oxidative stress and inflammatory parameters in Wistar rats.
We investigated the potential benefits of rutin nanoparticles in treating rheumatoid arthritis in a rat model. Sixty male rats were divided into groups and received different treatments, including rutin formulations and a positive control drug.
Our results showed that treatment with rutin nanoparticles improved behavior and reduced signs of inflammation in the rats. Notably, they decreased harmful substances while boosting beneficial ones, enhancing overall health indicators.
While these findings are promising, it’s important to note that further studies are needed to fully understand the efficacy in humans.
9
Gelatin-based nanoparticles show promise
Dose-Dependent Efficacy of Umbelliferone and Gelatin-Coated ZnO/ZnS Core-Shell Nanoparticles: A Novel Arthritis Agent for Severe Knee Arthritis.
We aimed to understand how gelatin-coated zinc and sulfur nanoparticles could potentially treat rheumatoid arthritis, a common autoimmune disorder. Our research involved testing these smart nanoparticles on normal and arthritis-affected rats.
The results were promising; the nanoparticles reduced inflammation and joint swelling significantly. We observed that they lowered harmful cytokines while boosting beneficial antioxidant enzymes. However, we must note that the effectiveness varied based on dosage, and no definitive conclusions were reached regarding their overall impact on rheumatoid arthritis in humans.
References
Yang R, Yan L, Xu T, Zhang K, Lu X, et al. Injectable bioadhesive hydrogel as a local nanomedicine depot for targeted regulation of inflammation and ferroptosis in rheumatoid arthritis. Biomaterials. 2024;311:122706. doi:10.1016/j.biomaterials.2024.122706
Jori C, Ansari MM, Ahmad A, Ali N, Raza SS, et al. Biomaterial-based combinatorial approach of aescin-comprised zein-coated gelatin nanoparticles alleviates synovial inflammation in experimental inflammatory arthritis. Nanoscale. 2024;16:7965. doi:10.1039/d3nr06476j
Gravandi MM, Pourmanouchehri Z, Behbood L, Fakhri S, Mohammadi-Noori E, et al. Rutin-loaded chitosan nanoparticles alleviated Freund's adjuvant induced rheumatoid arthritis via modulating oxidative stress and inflammatory parameters in Wistar rats. Naunyn Schmiedebergs Arch Pharmacol. 2024;397:4771. doi:10.1007/s00210-023-02902-x
Ain QU, Zeeshan M, Mazhar D, Zeb A, Afzal I, et al. QbD-Based Fabrication of Biomimetic Hydroxyapatite Embedded Gelatin Nanoparticles for Localized Drug Delivery against Deteriorated Arthritic Joint Architecture. Macromol Biosci. 2024;24:e2300336. doi:10.1002/mabi.202300336
Zheng Y, Lakshmanan S. Dose-Dependent Efficacy of Umbelliferone and Gelatin-Coated ZnO/ZnS Core-Shell Nanoparticles: A Novel Arthritis Agent for Severe Knee Arthritis. Oxid Med Cell Longev. 2022;2022:7795602. doi:10.1155/2022/7795602
Khunmanee S, Chun SY, Ha YS, Lee JN, Kim BS, et al. Improvement of IgA Nephropathy and Kidney Regeneration by Functionalized Hyaluronic Acid and Gelatin Hydrogel. Tissue Eng Regen Med. 2022;19:643. doi:10.1007/s13770-022-00442-8
Nieto-Aristizábal I, Vivas ÁJ, Ruiz-Montaño P, Aragón CC, Posso-Osorio I, et al. Therapeutic Plasma Exchange as a Treatment for Autoimmune Neurological Disease. Autoimmune Dis. 2020;2020:3484659. doi:10.1155/2020/3484659